A new generation of sexual enhancers may have found themselves in a new world of possibilities in the battle against erectile dysfunction (ED).
Sildenafil, an FDA-approved drug for treating pulmonary arterial hypertension, has been tested in clinical trials in men with ED who do not respond to a typical sildenafil dose. Sildenafil has been found to have similar safety and effectiveness to standard treatment of ED, Viagra. The drug is not approved for the treatment of pulmonary arterial hypertension in the United States. Sildenafil is available as 25mg tablets, 50mg tablets, and 100mg tablets in a convenient, blister-free, and easy-to-swallow form.
Sildenafil is available as a generic equivalent of Viagra. The drug is approved for the treatment of ED in men.
The drug has been found to be effective in treating patients with ED by increasing blood flow to the penis.
Sildenafil is used to treat the conditions of the ED, such as erectile dysfunction, and pulmonary arterial hypertension. Sildenafil belongs to a class of medications called phosphodiesterase type 5 (PDE5) inhibitors.
Sildenafil works by relaxing and dilating the smooth muscles in the walls of the blood vessels, which in turn increases the flow of blood to the penis.
Sildenafil is used to treat pulmonary arterial hypertension and is also used to treat other conditions such as pulmonary arterial hypertension and erectile dysfunction.
Sildenafil works by inhibiting the enzyme PDE5, which is found in the corpus cavernosum of the penis. This makes it easier for the penis to become erect and allows blood to flow more freely into the penis.
Sildenafil helps to reduce the size of the blood vessels and relax the muscles in these vessels, allowing blood to flow more easily.
Like any drug, sildenafil can cause side effects. The most common adverse effects associated with Sildenafil include headache, flushing, nasal congestion, and upset stomach. Serious side effects include priapism (prolonged and painful erection), sudden vision or hearing loss, and chest pain. Serious side effects of sildenafil include an erection lasting more than 4 hours, priapism (prolonged and painful erection), painful ejaculation, and a prolonged, painful erection lasting longer than four hours. If you experience any serious side effects, such as chest pain, sudden vision or hearing loss, you should contact a doctor immediately.
Sildenafil comes in a single 50mg tablet and is typically taken as a single dose. It should be taken about 30 minutes before sexual activity. The recommended starting time is usually around 4 hours. Do not take more than one dose within a 24-hour period. To ensure a steady, effective dose, take sildenafil approximately one hour before sexual activity.
For best results, take sildenafil at least one hour before sexual activity and for the best effect, do not take more than one dose.
Sildenafil inhibits the phosphodiesterase type 5 (PDE5) activity of smooth muscle cells in the rat pulmonary arterial wall, increasing the diameter of the pulmonary artery (PA) and promoting vasodilation. We report the first evidence that Sildenafil enhances pulmonary vasodilation and improves pulmonary artery diameter in rats with PA and the effects of Sildenafil are mediated through activation of cGMP-specific phosphodiesterase type 5 (PDE5). Our results suggest that PDE5 is a critical component of pulmonary vasodilation, and Sildenafil-induced vasodilation is dependent on PDE5 activation.
Citation:Boucher-Gardaud-Lane, E, et al. (2016) Sildenafil inhibits the phosphodiesterase type 5 (PDE5) activity of smooth muscle cells in the rat pulmonary arterial wall, increasing the diameter of the pulmonary artery (PA) and promoting vasodilation. PLoS ONE 11(3): e005979. https://doi.org/10.1371/journal.pone.005979
Editor:Ajanta S. Kaur, Mahidol University, Thailand
Received:August 11, 2015;Accepted:August 20, 2015;Published:September 4, 2015
Copyright:© 2015 Boucher-Gardaud-Lane et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding:The French government has received funding from the French National Agency for Drugs and Medical Devices (ANSM) for this work. The French National Agency for Drugs and Medical Devices has also received funding from the Federal Government of the Federal Republic of Germany (FEDERD) for the research on the effect of Sildenafil on pulmonary arterial smooth muscle cells. The French National Agency for Drugs and Medical Devices (ANSM) has received funding from the Federal Government of the Federal Republic of Germany (FEDERD) for the research on the effect of Sildenafil on pulmonary arterial smooth muscle cells.
Competing interests:The authors have declared that no competing interests exist.
Pulmonary arterial hypertension (PAH) is a chronic, progressive disease in humans that affects the lungs and is characterized by a progressive drop in blood pressure (BP) that can lead to life-threatening or fatal complications [,]. PAH is the most prevalent form of PA and is characterized by chronic, uncontrolled and progressive disease. In clinical practice, PAH can be caused by various factors, including obesity, underlying vascular disease, chronic inflammatory and autoimmune diseases, hormonal therapies and surgical procedures, and environmental toxins [–].
Pulmonary artery stenosis is a progressive condition that occurs in the right-sided arteries of the pulmonary arteries, where the narrowing of the pulmonary arteries is caused by vascular occlusion [,, ]. This process is triggered by vascular smooth muscle cell growth and injury, which results in relaxation of the smooth muscle cells and increased expression of phosphodiesterase type 5 (PDE5) []. PDE5 inhibitors are selective phosphodiesterases, which in turn inhibit the PDE-5 enzyme []. PDE5 is involved in the degradation of cGMP, a substance that mediates muscle contraction and relaxes smooth muscles in the pulmonary artery []. PDE5 inhibitors block phosphodiesterase type 5, and its inhibition decreases the expression of PDE5 in pulmonary smooth muscle cells and in endothelial cells [].
Sildenafil (Viagra) is a PDE5 inhibitor, and it has been widely studied as a treatment for PAH. Sildenafil has been shown to reduce the progression of PAH by enhancing pulmonary arterial vasodilation, and its anti-hypertensive effects have been investigated in clinical trials [, ]. However, it is difficult to determine whether Sildenafil does not significantly enhance pulmonary artery diameter and pulmonary artery pressure in the rat model of PAH. To our knowledge, only one study has investigated the effects of Sildenafil on pulmonary artery diameter in rats [].
Viagra has been shown to cause some mild side effects. Talk to your health care provider if these do not go away within a few days. If you begin to experience more serious reactions, seek medical attention immediately.
Common side effects reported from Viagra use include:
More severe side effects include:
If you experience any of these side effects, seek medical attention immediately. These are symptoms of a severe adverse reaction to this medication that require immediate treatment.
As with all prescription medications, inform your doctor of any medical conditions you currently manage. Tell them about any and all medications, prescription drugs, and supplements you are taking before starting treatment with Viagra. Viagra can interact with bodily substances, causing potentially serious adverse reactions.
Specifically, you should inform your health care provider of any nitrate medication you are taking. Remember to mention any herbal products you use, especially St. John’s wort.
In addition, let your doctor know if you have recently had heart surgery or experience chest pain during sex. If you experience any changes in your heartbeat or chest pain during sex, contact your health care provider immediately.
Tell them if you may experience dizziness, headache, heart attack, or rash. As with all prescription medications, inform your doctor if you experience any sexually transmitted diseases before starting Viagra. boasts of a natural herbal supplement called St. John’s wort that contains wortnios root. This wort was developed by scientists at the University of Southern California and is used to treat African toads, South Asian toads, and lemurs. The St. John’s wort is also used to treat the symptoms of an enlarged prostate and a urinary tract infection.Wonders about the benefits of St. John’s wort? Read on as it’s been shown to provide a similar benefits to that of Viagra. The wort is available as a purified extract, a soluble extract, or a mixture of extracts. Additional benefits of the St. John’s wort are listed in the next section.
St. John’s wort is a natural extract from the African plant St. This plant contains the natural St. John’s wort extract, a soluble extract, and the natural St. John’s wort extract, a blend. John’s wort is an annual or perennial plant that is native to North America, Europe, and South America. The wort is used to treat conditions like heart disease, diabetes, and hypertension.
John’s wort is available in capsule form and in strengths of 25 mg, 50 mg, 100 mg, 200 mg, and 300 mg. The capsules typically contain 100 mg St. John’s wort extract. Other strengths may be prescribed by your health care provider.
If you are using Viagra, your doctor may recommend that you supplement with a blend of St. John’s wort and other plant extracts. The supplement should be taken at least 2 hours before or after your Viagra prescription.
Viagra, like all prescription medications, may cause side effects.
Viagra Connect is a new erectile dysfunction treatment which does not require a prescription.
The first of its kind, Viagra Connect is a safe and discreet over-the-counter medication that can legally be bought online without a trip to your doctor.
We need to ensure that this medicine is suitable for the person it is intended for. Therefore, it should only be purchased by the person taking it.
A pharmacist may need to contact you by phone before providing the product. If they cannot reach you within 72 hours, your order may be delayed, or this item may be cancelled from your order.
Please ensure your contact details are correct before ordering this medicine.Suitable forViagra Connect is for men 18 years and older who have difficulty getting and/or keeping an erection hard enough for sex
Age RestrictionYou must be at least 18 years old to purchase this product.
Directions for use:Please read the enclosed leaflet carefully before use.
• take 1 tablet approximately one hour before sexual activity• swallow tablet whole with water• do not take more than 1 tablet a dayViagra Connect starts to work within 30-60 minutes. You may take it up to 4 hours before sexual activity.
Hazards and Cautions
Do NOT take if you:
Talk to your pharmacist or doctor before taking if you:
As with all medicines, please ensure you read the patient information leaflet before taking this item.
Please note that this medication is not expected to cause side effects. It is important to consult your doctor before taking any medicine.If you side- prepaid the load, we will check in with you again in due course.
There is no generic version of Viagra Connect. As with all medicines, this item has been requested as it may be suitable for people over 18 years of age.
If you are under 18, you understand that medicines are most important now. Your health and well-being are our priority. Be the first to read the information leaflet that we provide to your articles. We also provide advice and pro tag support in our articles.As long as this item is unshipping it (see DISCOUNT DISCLoses Entitlement to CondemDeclineIndecyanate, Prescriptions, Copay Cards, or Disclaimer), we will check in with in due course.No product has been approved as a new medication by the FDA. This medication is FDA-approved for use inMen 18 years and older.Active ingredient: Viagra Connect 10mg.
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